PCOS is complex but the right supplements can truly make a difference. When it comes to managing PCOS naturally, three supplements stand out for their science backed benefits: 1) Berberine often compared Vital Nutrients , Vital Brain Powder Lemon 180 Grams Liquid L Carnitine 3000: Metabolism & Energy Support Cutler Nutrition L carnitine is a naturally occurring amino acid structure that is made in the human brain, liver, and kidneys. L carnitine plays a critical role in energy production, as it converts fat into energy. Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes New England Journal of Medicine