Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Liver specific Bcl3 Knockout Alleviates Acetaminophen induced Liver Injury by Activating Nrf2 Pathway in Male Mice Cellular and Molecular Gastroenterology and Hepatology Sex differences in glutathione metabolism and acetaminophen toxicity