5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Let's talk Tylenol Paracetamol (acetaminophen) There are many side effects that most people don't realize. OTC does not mean it is side effect free, especially with chronic use. Even just 4 days of Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. About Acetaminophen Overdose Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health