Metabolic functions of the liver Deranged Physiology Dysregulation of glutathione synthesis in liver disease ScienceDirect What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it The changing faces of glutathione, a cellular protagonist., Volume I Frontiers Research Topic Changes in Glutathione Content in Liver Diseases: An Update